POS0722 HISTOPATHOLOGICAL ANALYSIS OF LUPUS NEPHRITIS INCORPORATING BANFF CRITERIA EMPHASIZES THE IMPORTANCE OF TUBULOINTERSTITIAL CHANGES FOR CREATININE AND PROTEINURIA AT 12 MONTHS AFTER RENAL BIOPSY

Background: Lupus nephritis (LN) occurs in about 30-60% of patients with systemic lupus erythematosus (SLE). LN is associated increased mortality. Currently, the diagnosis relies on histopathologic characteristics according to ISN/RPS classification (1). This heavily glomerular changes and may not accurately reflect all occurring LN. For description transplanted kidney, BANFF has been established which, addition changes, also incorporates tubular pathologies (2). Objectives: With present study, we aim describe a single-center cohort patients. Methods: We retrospectively recorded epidemiological, clinical laboratory data 58 over ten-year period. Histopathologic diagnoses or former WHO were documented. then re-analyzed representative kidney samples performed Spearman rank correlation for findings creatinine at biopsy 12 months as well proteinuria months. Results: analyzed 9 male, 49 female. Median age was 38 (15-78) years. According ISN/RPS, 3 had class I LN, 6 II, 14 III, 16 IV, V, 0 VI. eGFR 60 ml/min/1.73m2 (13-137). classification, tubulointerstitial inflammation (ti) Proteinuria interstitial fibrosis (ci) (Figure 1). Conclusion: In current puts emphasis changes. Nevertheless, long-term outcome, (tubulointerstitial fibrosis) least be important These have corroborated larger cohorts prespecified renal endpoints. References: [1]Weening et al. The glomerulonephritis revisited. JASN 2004. [2]Jeong HY. Diagnosis transplant rejection: Banff beyond. Kidney Res Clin Pract 2020. Disclosure Interests: Marlene Plüß: None declared, Samy Hakroush: Noah Niebusch: Björn Tampe: PETER KORSTEN Speakers bureau: Abbvie, Pfizer, Chugai, Sanofi, Boehringer-Ingelheim, GSK, Novartis, Consultant of: Lilly, Gilead, Grant/research support from: GSK